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- Aluminum Runway 57cm (OD) 45cm (ID) with 24cm walls
- Overall dimensions 87cm x 64cm x 64cm (H)
- Heater and heater/cooler on opposite sides, to establish a symmetric gradient
- Heating device: from room temperature to 65°C
- Heating/cooling device: from 4°C to 35°C
- Temperature feedback: 4 thermocouples embedded in the runway
- 12 zones per side, temperature of each zone measured by ANY-maze
- 4 infra-red and visible lights
- USB camera tracks the animal’s position within the ring
- ANY-maze reports 7 TGR specific measures, including:
– Preference Temperature ± SD
– Skew
– % time above a specific temperature - Measures can be reported for the entire test and across time
Thermal gradient ring
The Thermal Gradient Ring (TGR) provides an automated measurement of neuropathic pain without observer bias or interpretation. The device represents a thermal gradient assay designed as a circular running track. Animals are given a high degree of thermal choice which eliminates the potential for experimenter bias present in comparable assays. Based on its novel design freely moving animals explore a circular track divided into 12 thermal zones.
ANY-maze logically and automatically creates these zones and calculates the temperatures using embedded thermocouples. Furthermore, ANY-maze tracks the animal’s movement within the ring via a USB camera (supplied). The unique circular design guarantees no border effects and no spatial cues. Additionally, exploratory behaviour is easily discerned from thermal selection behaviour and provides increased accuracy by providing measured values in duplicate and by removing edge artefacts.
TGR is ideal for recording and analysis of Comprehensive Thermal Preference Phenotyping in Mice as described in Zimmermann’s method.
Details
Publications
Valek L. et al. (2021) Prodromal sensory neuropathy in Pink1−/−SNCAA53T double mutant Parkinson mice. Neuropathol Appl Neurobiol. 2021;00:1–20. https://doi.org/10.1111/nan.12734